Daclizumab high-yield process in the treatment of relapsing–remitting multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECTION): a multicentre, randomised, double-blind extension trial.
BACKGROUND In the SELECT trial, disease activity was reduced in patients with multiple sclerosis who received daclizumab high-yield process (HYP) for 52 weeks. The primary aim of the SELECTION extension study was to assess the safety and immunogenicity of extended treatment with daclizumab HYP. METHODS A multicentre, randomised, double-blind, 52-week extension trial was done in 74 centres in ...
متن کاملIntrathecal effects of daclizumab treatment of multiple sclerosis.
OBJECTIVES We previously reported that daclizumab, a humanized monoclonal antibody against CD25, reduced contrast-enhancing lesions (CEL) in patients with multiple sclerosis (MS) who were suboptimal responders to interferon-β and that this response correlated with expansion of CD56(bright) NK cells. These data have been reproduced in a placebo-controlled multicenter trial (CHOICE study). The cu...
متن کاملIntrathecal effects of daclizumab treatment of multiple sclerosis
Raphael Schneider, MD Nathalie Arbour, PhD The topic of this Journal Club is a study by Bielekova et al.,1 who assessed whether daclizumab monotherapy reduces contrast-enhancing lesions (CEL) in patients with relapsing-remitting multiple sclerosis (RRMS). Furthermore, they evaluated the effects of daclizumab on clinical outcome measures and on NK cell populations in the CSF and blood of treated...
متن کاملJournal club: Intrathecal effects of daclizumab treatment of multiple sclerosis.
Raphael Schneider, MD Nathalie Arbour, PhD The topic of this Journal Club is a study by Bielekova et al.,1 who assessed whether daclizumab monotherapy reduces contrast-enhancing lesions (CEL) in patients with relapsing-remitting multiple sclerosis (RRMS). Furthermore, they evaluated the effects of daclizumab on clinical outcome measures and on NK cell populations in the CSF and blood of treated...
متن کاملDaclizumab (anti-CD25) in multiple sclerosis.
Multiple sclerosis (MS) is a typical CD4 T cell-mediated autoimmune disease of the central nervous system (CNS) that leads to inflammation, demyelination, axonal damage, glial scarring and a broad range of neurological deficits. While disease-modifying drugs with a good safety profile and moderate efficacy have been available for 20 years now, a growing number of substances with superior therap...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Neurological Disorders
سال: 2016
ISSN: 1756-2864,1756-2864
DOI: 10.1177/1756285616671887